Third Harmonic Filter solved Chromatography System failures
Third Harmonic Filter | In about 18 months during 2019–20, the HPLC chromatography machines and detectors have reported over 150 failure, and unwanted detector rebooting problems at this pharma company production lines. The HPLC chromatography machine comprises an autosampler and a detector system. They are powered, each by an LVPC Logic Board that converts 230V UPS output power into various dc voltages. System failure and malfunction used to happen with LVPC logic boards, solenoid valves and electromechanical components which got mitigated after installing 2nos third harmonic filters (also called triplen harmonic filter) across each 100kva UPS output in one plus one hot standby mode. Also, each UPS had a 150KVA isolation transformer at its output power.
Causes of HPLC Chromatography System failure and detector rebooting as solved in the waters alliance machine at this Pharma Company.
A) Alliance HPLC system — Injection mechanism for samples and testing — Auto Sampler.
1. 55 Failure incidents reported with Electronic parts related to Solenoid valves and Electromechanical components.
2. 15 Failure incidents reported with Electronic PCB related to LVPC and Logic Board.
B) Detector — Sample analysis, reporting and data communication.
3. 47 Failure incidents reported with Electronic parts.
4. 33 Failure incidents reported with Electronic PCB related to LVPC and Logic Board.
5. In-addition several rebooting issues happened in the Detection unit of the HPLC system. Most reboots happened through the 5V supply of the LVPC logic board, which store testing data for transmission to other systems.
Furthermore, Infirmness in Neutral Wire with Third Harmonic Current is a serious Electrical Fire Risk. Its degree determines how soon the electrical fire would ignite. Computer, SMPS power supplies, Single Phase UPS and Electronic devices, and LED lighting create triplen harmonic current, also known as third harmonic or zero sequence harmonic; which unlike the normal current and also the industrial harmonic currents, do not get cancelled at neutral but get added and triple at neutral. The high neutral current with associated high frequency triplen harmonic is the perfect recipe that cause infirmness in the neutral system.
A single infirmness at a wrong neutral point could ignite electrical fire at the whole building or at a building section or at an individual equipment. It is thus required to mitigate the triplen harmonics from section by section and floor by floor 3ph supply DB levels. It greatly narrows down electrical fire risk for the entire building.
Considering actual load currents at floor level DBs for most of Buildings, Shopping malls, IT-companies, Corporate head quarters etc, it is concluded that the following two sizes of triplen harmonic filter would cater for the 80% of clients’ requirement, and for the balance 20% higher size filters would be supplied on an individual client’s need basis.
